Impaired Wnt–β-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
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چکیده
منابع مشابه
Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding
Citation Bonocora, R. P. et al. " A Homing Endonuclease and the 50-nt Ribosomal Bypass Sequence of Phage T4 Constitute a Mobile DNA Cassette. Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefit...
متن کاملImpaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding
BACKGROUND The prevalence of obesity has increased dramatically worldwide. The obesity epidemic begs for novel concepts and therapeutic targets that cohesively address "food-abuse" disorders. We demonstrate a molecular link between impairment of a central kinase (Akt) involved in insulin signaling induced by exposure to a high-fat (HF) diet and dysregulation of higher order circuitry involved i...
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The assembly of primary cilia is dependent on intraflagellar transport (IFT), which mediates the bidirectional movement of proteins between the base and tip of the cilium. In mice, congenic mutations disrupting genes required for IFT (e.g., Tg737 or the IFT kinesin Kif3a) are embryonic lethal, whereas kidney-specific disruption of IFT results in severe, rapidly progressing cystic pathology. Alt...
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During embryonic development, the kidney epithelium originates from cells that undergo a mesenchymal to epithelial transition (MET). The reverse process, epithelium to mesenchyme transition (EMT), has been implicated in epithelial tumor progression and in the fibrosis that leads to end-stage kidney failure. Snail transcription factors induce both natural and pathological EMT, but their implicat...
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Kamyar Zahedi, John J. Bissler, Zhaohui Wang, Anuradha Josyula, Lu Lu, Paula Diegelman, Nick Kisiel, Carl W. Porter, and Manoocher Soleimani Division of Nephrology and Hypertension, Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2009
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.2010